If you’re exploring treatment options for Treatment-Resistant Depression or Major Depressive Disorder in New York, you’ve likely come across both SPRAVATO® and IV ketamine therapy. At NY Ketamine Infusions, we understand how overwhelming it can be to make the right choice for your mental health. We are preparing to offer SPRAVATO® at our clinics, an FDA-approved treatment for specific psychiatric indications, while continuing to provide IV ketamine as an established off-label option that has been safely used in clinical practice for more than a decade.
In this post, we’ll break down the differences and similarities between SPRAVATO® (esketamine) and IV ketamine infusion therapy, helping you make an informed decision tailored to your needs.
Comparing SPRAVATO® and IV Ketamine
Route of Administration
SPRAVATO® (esketamine) is FDA-approved for two indications: (1) Treatment-Resistant Depression (TRD) in adults, either alone or with an oral antidepressant, and (2) depressive symptoms in adults with Major Depressive Disorder (MDD) with acute suicidal ideation or behavior, in combination with an oral antidepressant.
As part of the FDA’s Risk Evaluation and Mitigation Strategy (REMS), SPRAVATO® must be administered on-site under direct medical supervision, with no option for home use. This means healthcare providers must observe you for at least two hours after your dose. NY Ketamine Infusions is REMS-certified, ensuring that all treatments are delivered in full compliance with these strict safety guidelines.
IV ketamine is delivered through an intravenous infusion in a private room under direct medical supervision, similar to SPRAVATO®, with both treatments requiring in-clinic administration and monitoring to ensure patient safety.
Dosing Flexibility
With SPRAVATO®, dosing follows standardized guidelines for the nasal spray. IV ketamine offers greater flexibility, since infusion doses can be adjusted based on your individual needs and response. Both treatments can play a role in a personalized plan developed by your care team.
Treatment Schedule
Both SPRAVATO® and IV ketamine begin with an initial treatment phase that follows a structured schedule. After this induction period, patients typically move to a maintenance plan, with visit frequency adjusted by the care team based on individual progress and response.
Insurance Considerations
Insurance coverage can differ significantly between these two treatments. SPRAVATO® is covered by most insurance plans, whereas IV ketamine is generally a self-pay treatment. Patients should confirm the details of their individual coverage directly with their provider.
What Makes Each Treatment Unique?
Both SPRAVATO® and IV ketamine are valid, evidence-backed options for treating severe depression, but each has its own characteristics that make it suitable for different individuals.
SPRAVATO® may be appealing because it is less invasive and is covered by most insurance plans. IV ketamine, on the other hand, allows for more flexibility in dosing and can be used for maintenance boosters as part of an individualized treatment plan.
Here at NY Ketamine Infusions, we ensure that whichever method you choose aligns with your personal needs and medical history.
Which Treatment Might Be Right for You?
The decision between SPRAVATO® and IV ketamine isn’t one-size-fits-all. Understanding your needs, preferences, and medical history is crucial for making the best choice.
Ask yourself:
- Do you prefer a nasal spray or an infusion?
- Are you looking for a more standardized treatment or something that can be tailored to your unique response?
Our compassionate team at NY Ketamine Infusions is dedicated to helping you navigate these choices, ensuring you receive guided care and expert support tailored to your needs.
Our Philosophy: Choice, Safety, and Evidence-Based Care
At NY Ketamine Infusions, we believe that the mental health of our patients comes first. With over 12 years of experience and more than 8,000 patients treated under the NYKI clinical team, we are proud to be one of the most experienced ketamine clinics in the nation.
We support both SPRAVATO® and IV ketamine treatment paths, reflecting our commitment to personalized care. Whether you opt for esketamine or ketamine infusion therapy, our priority is your safety, comfort, and well-being.
Important Safety Information:
Spravato® may cause sedation, dissociation, and respiratory depression, and it carries the potential for abuse and misuse. Patients should be closely monitored for suicidal thoughts and behaviors. Blood pressure will be monitored during and after treatment, and this medication is not recommended during pregnancy.
At NY Ketamine Infusions, we have treated more than 8,000 patients since opening in 2012. Spravato® is offered as an additional treatment option—complementing our longstanding IV ketamine program. Both modalities are supported by evidence and may suit different patient needs. Your care team will work with you to determine which path best aligns with your medical history and treatment goals.
Final Thoughts
Choosing the right treatment for your mental health is a significant decision, and one that should be based on your unique circumstances. Whether you are leaning toward SPRAVATO® or IV ketamine, NY Ketamine Infusions is here to help. We offer personalized consultations to discuss your options, treatment plans, and patient-centric care.
If you’re ready to explore your treatment options further, get in touch with NY Ketamine Infusions today.
This content is for informational purposes only and is not a substitute for professional medical advice. SPRAVATO® is only available through a certified treatment center under the FDA REMS program, with on-site monitoring and no home use permitted. Please see the Full Prescribing Information for additional safety details.