Treatment-Resistant Depression (TRD): For individuals who have not achieved desired results after trying at least two antidepressant therapies.
Major Depressive Disorder (MDD) with Acute Suicidal Ideation or Behavior: A fast-acting option for those experiencing severe depressive symptoms.
Response Rate:
Conventional antidepressant medications generally yield positive treatment responses in about 40% to 60% of patients. In contrast, clinical research on Spravato® (esketamine) has reported response rates reaching up to 70% (Popova et al., 2019, American Journal of Psychiatry).
Onset of Therapeutic Effect:
Whereas standard antidepressants may require between four to six weeks before users begin to notice any significant improvement, esketamine (Spravato®) has been associated with symptom relief in as little as 24 hours, according to clinical trial data (BMC Psychiatry, 2022).
Sustained Remission Rates:
In a clinical trial, 43.8% of individuals who continued treatment with Spravato alongside an oral antidepressant at the three-month mark had entered remission from major depressive episodes.
At NY Ketamine Infusions, SPRAVATO® offers you a new way to manage depression. Administered under the supervision of a healthcare provider, this nasal spray targets NMDA receptors in your brain, leading to fast and noticeable symptom relief.
You’ll receive SPRAVATO® in our certified treatment center, where you’ll be closely monitored for at least two hours after each session to ensure your safety and well-being.
Ask the Experts
What to Expect During Spravato Treatment
Spravato Patient Testimonial
1. Rapid Relief of Symptoms
Spravato can start working within hours or days, unlike traditional antidepressants that may take weeks. This speed can be life-saving for individuals facing severe depressive episodes.
2. Effective for Treatment-Resistant Depression
It’s FDA-approved for people who haven’t responded to at least two other antidepressants. Spravato gives a new option when nothing else seems to work.
3. Reduces Suicidal Thoughts
Spravato has been shown to reduce suicidal thinking in people with major depression, offering fast-acting support during mental health crises.
4. Works Differently Than Traditional Antidepressants
Instead of targeting serotonin or dopamine, Spravato affects the brain’s glutamate system. This unique mechanism may offer relief where standard medications fail.
5. Monitored, In-Clinic Use for Safety
Spravato is only administered under medical supervision at certified treatment centers. This ensures safety, controlled dosing, and immediate support if side effects occur.
We start with a free phone consultation, followed by a thorough evaluation of your medical history and treatment needs to determine Spravato eligibility. If qualified, we verify insurance with major providers. Services are offered in NYC, Long Island, and Westchester, NY.
Once approved, we’ll schedule your first SPRAVATO® session. You’ll self-administer the nasal spray in a safe, calm clinic setting under medical supervision. Our team monitors you for at least two hours to ensure your well-being and manage any side effects.
Your treatment begins with an induction phase, typically involving twice-weekly sessions. As you progress, this shifts to a maintenance phase with less frequent visits, adjusted to support your individual mental health needs and long-term goals.
We stay with you throughout your journey, providing consistent check-ins to track your progress and address any issues. Your care plan evolves as needed, in coordination with your referring provider, ensuring you have the support and tools for lasting mental wellness.
Week 1-4
2 Treatments a Week
Week 5-8
1 Treatments a Week
Week 9+
1 Treatment a Week Every 1-2 Weeks
At NY Ketamine Infusions, we deliver care that’s grounded in rigorous clinical standards. Every treatment follows evidence-based protocols reviewed by leading anesthesiologists and mental health professionals. Your safety isn’t a feature—it’s the foundation.
We believe healing is as much about where you receive care as how. That’s why our infusion suites are designed for calm, comfort, and privacy—creating an experience that supports emotional ease as well as therapeutic outcomes. A space that feels safe is a space where healing starts.
We value collaboration. Whether you're already working with a psychiatrist, therapist, or primary care provider, we coordinate care with your permission to ensure continuity and clarity, so you don’t have to navigate your mental health journey alone.
Breakthrough care shouldn't come with endless forms or financial hurdles. NY Ketamine Infusions accepts insurance for eligible treatments and manages the paperwork on your behalf, because healing should be accessible, not bureaucratic.
SPRAVATO® (esketamine) is an FDA-approved nasal spray designed for adults with treatment-resistant depression (TRD). Unlike traditional antidepressants that target serotonin and dopamine, SPRAVATO® works on NMDA receptors, helping to restore balance in brain function and providing relief for those who have not responded to standard treatments.
SPRAVATO® is intended for adults with treatment-resistant depression who have tried at least two different oral antidepressants without sufficient improvement. As of January 2025, the FDA has approved SPRAVATO® as a standalone treatment, meaning it no longer requires combination therapy with oral antidepressants. A consultation with a provider at NY Ketamine Infusions will determine if SPRAVATO® is right for you.
Each session takes place in a comfortable, supervised setting at NY Ketamine Infusions. You will self-administer the nasal spray under medical supervision. Afterward, you will be monitored for at least two hours for any potential side effects before being cleared to leave.
Many patients report feeling relief within 24 hours of their first few treatments. However, results vary, and a full treatment plan typically involves an induction phase (twice weekly for four weeks) followed by a maintenance phase based on your progress.
Common side effects include temporary dizziness, nausea, drowsiness, or dissociation (feeling detached from reality). These effects usually subside within a few hours. To ensure safety, patients are monitored closely during and after treatment.
No. Due to possible sedation and dissociation effects, you must arrange for someone to drive you home after each session. Patients should also avoid operating heavy machinery for the rest of the day.
The treatment schedule typically includes two sessions per week for the first four weeks, followed by a tapered maintenance phase depending on individual response. Your provider will tailor a plan based on your needs.
Coverage for SPRAVATO® is available through many leading insurance companies, though the extent of coverage can differ depending on your specific plan. At NY Ketamine Infusions, their dedicated team will help you confirm your insurance benefits and work to reduce your out-of-pocket expenses as much as possible.
SPRAVATO® is FDA-approved for standalone use and covered by insurance, whereas IV ketamine infusions are often out-of-pocket expenses. Additionally, SPRAVATO® is administered as a nasal spray in a certified treatment center, while ketamine infusions require an IV.
To begin treatment, schedule a consultation with NY Ketamine Infusions. Our team will evaluate your medical history, confirm eligibility, and create a personalized treatment plan to help you find relief from depression.
75 Maiden Lane, 10th Floor
New York, NY 10038
Treatment Hours:
7 days a week:
9AM to 7PM
150 Broadhollow Rd, Suite 103
Melville, NY 11747
Treatment Hours:
Monday, Wednesday, Friday
9AM to 5PM
222 Westchester Ave STE 306
West Harrison, NY 10604
Treatment Hours:
Monday, Wednesday, Friday
9AM to 5PM
