LOCATIONS: NEW YORK CITY | LONG ISLAND
Curious about starting treatment? Give us a call at (917)-261-7370 or book a free consultation to learn more!
Living with bipolar disorder means navigating unpredictable shifts from deep depression to high-energy mania. Traditional mood stabilizers and therapies are essential, yet many patients still experience breakthrough symptoms or delayed relief.
At our New York ketamine infusion centers—in Manhattan, Long Island, and Westchester—we offer sub-anesthetic ketamine treatments designed to rapidly rebalance neural circuits and provide relief when you need it most.
Bipolar disorder involves dysregulation in glutamate and GABA systems as well as downstream effects on synaptic connectivity. Ketamine, by blocking NMDA receptors on inhibitory interneurons, triggers a controlled surge of glutamate in the prefrontal cortex and hippocampus.
That glutamate binds to AMPA receptors, activating the mTOR pathway and promoting new synapse growth. In plain terms, ketamine gives your brain a reset button—strengthening connections that stabilize mood and interrupt the roller-coaster of highs and lows.
While lithium and anticonvulsants remain the backbone of long-term management, their onset can take weeks. Multiple controlled trials have shown that a single IV infusion of ketamine (0.5 mg/kg over 40 minutes) often yields significant improvement in depressive symptoms within 4–24 hours—and can blunt manic or hypomanic spikes as well.
For patients experiencing suicidal ideation or severe mood lability, that speed can be life-saving. Maintenance protocols (twice-weekly infusions tapering to every 2–4 weeks) help sustain stability as you work with your psychiatrist to optimize your overall regimen.
Your first visit kicks off with an in-depth assessment: medical history, current medications, and baseline labs to ensure safety. On treatment days, you’ll recline in a private infusion suite as ketamine drips steadily through an IV line under the watchful eye of our clinical team.
Vital signs, mood scales, and any perceptual experiences are monitored throughout the 40-minute infusion and for at least one hour afterward.
Post-infusion, many patients report enhanced mood stability, clearer thinking, and reduced irritability—often surprising even seasoned clinicians with how swiftly change can occur.
Ketamine therapy is best suited for adults whose bipolar disorder remains partially uncontrolled despite two or more mood stabilizers or whose rapid cycling interferes with daily life.
We screen carefully for cardiovascular health and any history of substance misuse, since ketamine can transiently raise blood pressure and carry mild dissociative effects.
Under our team’s supervision, the balance of risk and reward clearly favors patients in need of quicker, more robust symptom relief.
Most patients begin with an induction phase—two infusions per week for three weeks—followed by maintenance treatments spaced according to individual response (often every three to six weeks).
We collaborate closely with your prescribing psychiatrist to adjust oral medications as ketamine takes effect.
Many find that combining infusions with psychotherapy or structured mood-management groups amplifies and prolongs benefits, helping new neural pathways translate into lasting lifestyle changes.
Under clinical protocols, temporary spikes in heart rate or blood pressure, mild nausea, and brief dissociative sensations (“floating” or dream-like) are expected and immediately managed.
Because recreational, high-dose ketamine can impact bladder function, our dosing remains conservative and tightly scheduled. Follow-up visits ensure any emerging concerns—physical or psychological—are addressed before the next session.
Whether you’re in Manhattan, on Long Island, or up in Westchester, our New York ketamine infusion clinics are here to support your journey toward balanced mental health.
Contact us today to schedule a consultation and discover if ketamine for bipolar disorder is the breakthrough you’ve been looking for.
Conditions Treated
75 Maiden Lane, 10th Floor, New York, NY 10038
Phone: 917-261-7370
Treatment Hours:
7 days a week: 9AM to 7PM
150 Broadhollow Rd, Suite 103, Melville, NY 11747
Phone: 631-629-4626
Treatment Hours:
Monday, Wednesday, Friday from 9AM to 5PM
Our protocol requires a brief intake conversation with one of our physicians to determine if ketamine is likely to help you. Please fill out the form below and you will be contacted by our Patient Care Team within 24 hours. After submitting, you’ll get the opportunity to provide more personal information via an optional questionnaire.
